Here are some of my favourite studies on using DNA in your practice which might get you as excited as it makes me.
1) 2016 study by Papadimitrious et al.:
Whenever I watch the Olympics, it always gets me wondering how much is genetics and how much is their environment.
Is there really such a thing as a speed gene?
Despite sprint performance relying on many different factors, the researchers on this paper found that the ACTN3 gene and the ACE gene can account for 0.92% and 1.48% of sprint time, respectively.
2) 2009 study by Tsianos et al.:
Researchers looked at 438 athletes who completed the Olympus Marathon (a marathon from sea level to 2,690-m altitude).
Most of the athletes who were able to complete this monstrous race had a favourable version of the BDKRB2 gene.
Of all the athletes that completed the race, those who had the fastest time usually had the favourable version of the ADRB2 gene.
That included the athlete who had the fastest time ever for this race.
3) 2004 study by Collins et al.:
A study was done on 447 participants of the South African Ironman Triathlon. The researchers found that how fast you were able to finish the entire race might be influenced by which variation of the ACE gene you had.
The fastest 100 finishers all had the greatest distribution of the I allele, the slowest 100 finishers had an intermediate amount, and the control group had the least.
This linear trend suggests that your client’s ACE genotype may have an effect on their endurance performance.
References
1) Papadimitriou ID, Lucia A, Pitsiladis YP, Pushkarev VP, Dyatlov DA, Orekhov EF, Artioli GG, Guilherme JP, Lancha AH Jr, Ginevičienė V, Cieszczyk P, Maciejewska-Karlowska A, Sawczuk M, Muniesa CA, Kouvatsi A, Massidda M, Calò CM, Garton F, Houweling PJ, Wang G, Austin K, Druzhevskaya AM, Astratenkova IV, Ahmetov II, Bishop DJ, North KN, Eynon N. ACTN3 R577X and ACE I/D gene variants influence performance in elite sprinters: a multi-cohort study. BMC Genomics. 2016 Apr 13;17:285. doi: 10.1186/s12864-016-2462-3. PMID: 27075997; PMCID: PMC4831144.
2) Tsianos GI, Evangelou E, Boot A, Zillikens MC, van Meurs JB, Uitterlinden AG, Ioannidis JP. Associations of polymorphisms of eight muscle- or metabolism-related genes with performance in Mount Olympus marathon runners. J Appl Physiol (1985). 2010 Mar;108(3):567-74. doi: 10.1152/japplphysiol.00780.2009. Epub 2009 Dec 31. PMID: 20044476.
3) Collins M, Xenophontos SL, Cariolou MA, Mokone GG, Hudson DE, Anastasiades L, Noakes TD. The ACE gene and endurance performance during the South African Ironman Triathlons. Med Sci Sports Exerc. 2004 Aug;36(8):1314-20. doi: 10.1249/01.mss.0000135779.41475.42. PMID: 15292738.
Written by Kyle van Heerden
Online Educator at Research Raconteur
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